Which result may indicate a therapeutic effect of tricyclic antidepressants?

A therapeutic effect of tricyclic antidepressants is often indicated by enhanced mood and emotional stability. These medications are primarily used to treat depression and can result in significant improvements in a person's overall mood and ability to manage emotions. This improvement aligns with the pharmacological action of tricyclics, which work by increasing the levels of neurotransmitters like norepinephrine and serotonin in the brain. When these neurotransmitter levels are balanced, individuals typically experience a reduction in depressive symptoms, leading to a more stable emotional state and an overall better quality of life.

While improved appetite and weight gain, decreased frequency of nightmares, and increased energy levels and motivation can also be associated with therapeutic benefits, they are not as direct indicators of the primary aim of treatment with tricyclic antidepressants, which is to alleviate depressive symptoms and enhance mood. Thus, the enhancement of mood and emotional stability is the most significant result that reflects the effectiveness of these agents in managing depression.