Which of the following is a common side effect associated with tricyclic antidepressants?

Orthostatic hypotension is a common side effect associated with tricyclic antidepressants (TCAs) due to their pharmacological effects on neurotransmitter systems. TCAs primarily work by inhibiting the reuptake of norepinephrine and serotonin, but they also have significant anticholinergic and antihistaminic properties. The blockade of these receptors can lead to vasodilation and a decrease in peripheral vascular resistance, which may result in orthostatic hypotension—a drop in blood pressure when standing up. This side effect is particularly important to monitor in patients, especially the elderly, as it can increase the risk of falls and related injuries.

While headaches, nausea, and weight gain can also occur with various antidepressants, they are not as uniquely associated with TCAs as orthostatic hypotension. Therefore, this side effect stands out when considering the specific profile and mechanism of action of tricyclic antidepressants.