Which of the following can be a potential withdrawal symptom from stopping antidepressants abruptly?

Withdrawal symptoms can occur when an individual suddenly stops taking antidepressants, especially those that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Flu-like symptoms are one of the most commonly reported withdrawal manifestations. These may include symptoms such as fatigue, muscle aches, chills, and malaise, similar to the common cold or influenza.

The development of these flu-like symptoms is associated with the body’s physiological adjustment to the sudden absence of medication that has been influencing neurotransmitter activity. When antidepressants are discontinued abruptly, the brain needs to recalibrate its chemical balance, which can lead to a temporary state of discomfort characterized by these flu-like symptoms. This phenomenon highlights the importance of tapering off antidepressants under medical supervision to minimize withdrawal effects.

The other options—like increased appetite, enhancement of mood, and improved sleep quality—are not typically associated with withdrawal symptoms. Rather, they may reflect outcomes of effective treatment or unrelated changes in an individual's mental or physical state.