Which class of antidepressants is known for its sedative effects?

Tricyclic antidepressants (TCAs) are known for their sedative effects, which primarily arise from their ability to block histamine H1 receptors in addition to their antidepressant properties. This sedative quality can be beneficial for patients who experience insomnia or high levels of anxiety alongside their depression, as it may help improve sleep patterns and provide a calming effect.

In contrast, selective serotonin reuptake inhibitors (SSRIs) typically have a more activating effect on the central nervous system and are less associated with sedation. Monoamine oxidase inhibitors (MAOIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) can also vary in their sedative properties depending on the individual medication and patient response, but they generally do not carry the same notable sedative characteristics as tricyclic antidepressants. Thus, when considering which class of antidepressants is best known for inducing sedation, tricyclic antidepressants stand out clearly.