Which antidepressant's mechanism of action involves reuptake inhibition specifically of norepinephrine and serotonin?

Tricyclic antidepressants (TCAs) primarily exert their effects by inhibiting the reuptake of norepinephrine and serotonin in the synaptic cleft. This dual inhibition enhances the availability of these neurotransmitters, which is believed to play a significant role in alleviating the symptoms of depression.

The mechanism of action of TCAs is broader compared to some other classes of antidepressants, which may target only one neurotransmitter. While monoamine oxidase inhibitors block the breakdown of various neurotransmitters, they do not specifically focus on reuptake inhibition. Both selective serotonin reuptake inhibitors and atypical antidepressants have more specific mechanisms, either targeting serotonin selectively or engaging multiple neurotransmitter systems in various ways, none of which encompasses the comprehensive reuptake inhibition of both norepinephrine and serotonin as TCAs do.

Thus, the ability of tricyclic antidepressants to influence the levels of both norepinephrine and serotonin through reuptake inhibition aligns precisely with what was inquired in the question, marking them as the appropriate answer.