Which antidepressant is known for its norepinephrine-dopamine reuptake inhibitor (NDRI) mechanism?

Bupropion is known for its unique mechanism of action as a norepinephrine-dopamine reuptake inhibitor (NDRI). This means that it works by blocking the reuptake of the neurotransmitters norepinephrine and dopamine in the brain, thereby increasing their availability in the synaptic cleft. This effect can help to improve mood and alleviate symptoms of depression in individuals who may not respond to other types of antidepressants.

In contrast, the other options listed are primarily selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Sertraline and fluoxetine, for example, primarily target serotonin levels in the brain, while duloxetine acts on both serotonin and norepinephrine reuptake. The distinct action of bupropion makes it particularly useful in certain cases, such as when an individual also needs support for attention deficits or when other antidepressant therapies have proven ineffective. Its stimulating effects on dopamine may also contribute to a lower incidence of sexual side effects compared to other antidepressants.