Which antidepressant is known for causing fewer sexual side effects compared to others?

Bupropion is often recognized for causing fewer sexual side effects compared to many other antidepressants. This is largely due to its unique mechanism of action, which primarily involves the inhibition of the reuptake of norepinephrine and dopamine, rather than serotonin. Many common antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) like paroxetine and sertraline, are associated with sexual side effects due to increased serotonergic activity. These can manifest as decreased libido, delayed ejaculation, or anorgasmia. Bupropion’s different pharmacological profile means that it tends to preserve sexual function better, which can be an important consideration for both patients and clinicians when selecting an antidepressant, especially for those who are concerned about potential impacts on sexual health.

Amitriptyline, a tricyclic antidepressant, also tends to carry the risk of sexual side effects due to its anticholinergic properties and effects on serotonin levels, making bupropion a preferable option in this regard.