Which antidepressant is contraindicated in patients with a seizure disorder?

Bupropion is contraindicated in patients with a seizure disorder due to its dose-dependent lowering of the seizure threshold. This means that as the dose of bupropion increases, the risk of seizures rises significantly, particularly in individuals who have a preexisting seizure condition. In contrast, other antidepressants listed, such as duloxetine, fluoxetine, and citalopram, do not have the same level of risk associated with seizures and are generally considered safer options for individuals with seizure disorders. Therefore, the choice of bupropion acknowledges the crucial aspect of ensuring patient safety in terms of neurological health when selecting antidepressant therapy.