Which antidepressant is contraindicated in patients with a history of seizure disorders due to its lowered seizure threshold?

Bupropion is contraindicated in patients with a history of seizure disorders primarily because it has been shown to lower the seizure threshold. This means that it increases the risk of seizures occurring in individuals who may already be predisposed to them. Unlike many other antidepressants, which do not significantly affect seizure threshold, bupropion can lead to an increased likelihood of seizures, especially when higher doses are used.

This characteristic makes it particularly important for clinicians to consider a patient's medical history, especially regarding seizures, before prescribing bupropion. Other antidepressants like sertraline, paroxetine, and citalopram have more neutral effects regarding seizure threshold and are not associated with the same risk. Therefore, they are generally safer options for patients with a history of seizures. In summary, bupropion's unique side effect profile concerning seizures is the key reason it is contraindicated in these patients.