Which antidepressant can improve sexual function compared to typical SSRIs?

Bupropion is known for its unique mechanism of action, which distinguishes it from typical SSRIs like fluoxetine, sertraline, and even tricyclic antidepressants like amitriptyline. While SSRIs are effective in treating depression and anxiety, they often come with side effects, particularly sexual dysfunction, which can be a significant issue for many patients.

Bupropion functions primarily as a norepinephrine-dopamine reuptake inhibitor (NDRI), which enhances the levels of dopamine and norepinephrine in the brain. This mode of action tends to have a more favorable impact on sexual function compared to SSRIs, which can inhibit serotonin reuptake but may lead to decreased libido, difficulty achieving orgasm, or erectile dysfunction.

Due to its stimulating effects and lack of serotonergic activity, bupropion often counters the sexual side effects associated with other antidepressants. This makes it a preferred choice for patients who are concerned about sexual side effects or who have experienced such problems on other medications.

In summary, bupropion's distinct pharmacological profile allows it to improve sexual function, making it a suitable alternative when treating depression for individuals who are also dealing with sexual dysfunction.