When might a patient experience an increase in the risk of suicide while taking antidepressants?

Patients may experience an increased risk of suicide during the initial treatment phase of antidepressants or when there is a change in their dosage. This heightened risk is particularly concerning in the early weeks of treatment when the antidepressant's full effects have not yet been realized. It is during this time that some patients might experience increased agitation, anxiety, or impulsivity, which could lead to suicidal thoughts or behavior.

The initial phase of starting an antidepressant can be a vulnerable time, especially for younger patients and those with a history of depression or suicidal ideation. Increases in dosage may also lead to fluctuations in side effects, which could contribute to feelings of instability or distress. Thus, close monitoring is advised during these critical periods for any signs of worsening depression or emerging suicidal thoughts.