What is an uncommon but serious side effect of bupropion?

Bupropion, an atypical antidepressant, is specifically known for its risk of seizures, particularly at higher doses. This side effect occurs because bupropion can lower the seizure threshold, making it more likely for seizures to occur when the medication is taken in higher amounts or in individuals with a history of seizures or certain medical conditions.

The risk of seizures is one of the primary concerns that clinicians have when prescribing bupropion, leading to guidelines that recommend avoiding doses that exceed 400 mg per day. This caution is especially important in the context of depression treatment, where medication dosages must be balanced with safety to achieve therapeutic efficacy.

Other side effects listed in the choices, such as rash or skin irritation, weight gain, and insomnia or sleep disturbances, can occur with various antidepressants but are not notable risks unique to bupropion. Rash may indicate an allergic reaction, weight gain is often a concern with certain other antidepressants more than bupropion, and insomnia tends to be a common consideration with many psychiatric medications. However, the potential for seizures stands out as an uncommon yet serious risk associated with bupropion that healthcare providers monitor closely.