What is an important consideration when prescribing antidepressants to elderly patients?

When prescribing antidepressants to elderly patients, a crucial consideration is the increased likelihood of experiencing more side effects compared to younger adults. This heightened risk arises due to several factors unique to this age group, such as age-related physiological changes, the presence of comorbid conditions, and polypharmacy, which often results in interactions between multiple medications.

Elderly patients typically have altered pharmacokinetics and pharmacodynamics, which can affect how the body absorbs, distributes, metabolizes, and eliminates medications. For instance, reduced liver and kidney function can lead to higher drug levels in the body and a prolonged duration of action, increasing the potential for side effects. Additionally, elderly patients may be more sensitive to the CNS effects of antidepressants, leading to issues such as sedation, falls, or cognitive impairment.

By recognizing these considerations, prescribers can take appropriate measures to monitor side effects closely and adjust treatment regimens to enhance safety and therapeutic benefit for elderly patients.