What is a common off-label use for mirtazapine?

Mirtazapine is commonly prescribed off-label for the treatment of insomnia due to its sedative properties. This antidepressant works primarily by altering neurotransmitter levels in the brain, particularly by antagonizing certain serotonin and norepinephrine receptors. The result is not only an improvement in mood in individuals with depression but also a significant sedative effect that can be beneficial for those struggling with sleep disturbances.

The sedative effects of mirtazapine can help individuals who experience difficulty falling asleep or staying asleep, making it a suitable option for managing insomnia. While other antidepressants may have activating properties that can worsen insomnia, mirtazapine’s sedative effects make it unique among many of its counterparts. This dual action is why healthcare providers may choose to prescribe mirtazapine specifically for sleep-related issues, even when a patient does not meet the full criteria for depression.