What is a common adverse effect of tricyclic antidepressants?

Tricyclic antidepressants (TCAs) are known for a variety of side effects, one of the most common being dry mouth, also referred to as xerostomia. This occurs due to the anticholinergic properties of TCAs, which inhibit the action of acetylcholine—a neurotransmitter that plays a crucial role in salivation. As a result, patients may experience a significant decrease in saliva production, leading to discomfort and potential complications such as dental issues if not managed properly.

This side effect is particularly noteworthy in clinical practice, as it can affect adherence to the medication. If a patient is aware that they may experience dry mouth, they can take preventive measures, such as staying hydrated or using saliva substitutes. Understanding this adverse effect is essential for healthcare providers, as it aids in better management of patient care and helps to mitigate discomfort associated with treatment.

While other options may also have some relation to various medications or conditions, they do not represent a common or significant adverse effect associated specifically with tricyclic antidepressants.