What could be a concern with venlafaxine if used in overdose scenarios?

In cases of venlafaxine overdose, a primary concern is the risk of serotonin syndrome. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that increases the levels of serotonin in the synapses of the brain. When it is taken in excessive amounts, there can be a significant elevation in serotonin levels, leading to this potentially life-threatening condition. Symptoms of serotonin syndrome may include agitation, confusion, rapid heart rate, dilated pupils, muscle rigidity, and, in severe cases, can progress to seizures or hyperthermia.

While other issues such as respiratory depression and seizures are relevant in the context of overdose with various medications, they are not the hallmark of venlafaxine specifically. Hypoglycemia is also less commonly associated with venlafaxine overdose, making serotonin syndrome a critical and defining concern when evaluating the risks associated with this medication in overdose scenarios.